Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities
作者： Mariella Gruber Filbin , Sukriti K Dabral , Maria F Pazyra-Murphy , Shakti Ramkissoon , Andrew L Kung
DOI: 10.1038/NM.3328
关键词: In vivo 、 PI3K signaling 、 Glioblastoma 、 Human brain 、 PTEN 、 Cancer research 、 Immunology 、 Biology 、 CNS cancer
摘要: This study identifies the concurrent activation of SHH and PI3K signaling by loss PTEN as a frequent event in glioblastoma tumors that can be targeted with combination treatments using approved drugs to achieve antitumor responses vivo. The results could potentially lead exploration much needed new therapies for human brain tumors.
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