Clinical outcome and prognostic analysis of young adults nasopharyngeal carcinoma patients of a nonendemic area in intensity-modulated radiotherapy era.
作者： Yecai Huang , Jingqiu Zhang , Qiao He , Mei lan , Mei Feng
关键词: Proportional hazards model 、 Intensity modulated radiotherapy 、 Nasopharyngeal carcinoma 、 Oncology 、 Survival rate 、 Internal medicine 、 Medicine 、 Retrospective cohort study 、 Radiation therapy 、 Young adult 、 Survival analysis
摘要: Aim To investigate the clinical outcome and prognostic factors of young adults nasopharyngeal carcinoma (NPC) patients in era intensity-modulated radiotherapy. Methods We retrospectively analyzed NPC who were admitted to our hospital from January 2010 December 2013. COX regression model was used identify associated with survival. The acute late toxicities also evaluated. Results A total 165 included; median follow-up time for all 65 months (4-96 months). 5-year overall survival (OS), distant metastasis-free survival, progression-free local-regional recurrence-free 85.9, 82.4, 76.4 92.4%, respectively. N stage an independent factor OS (p = 0.009) 0.008). Cumulative cisplatin >200 mg/m2 0.032). Conclusion Young can achieve a reasonable control radiotherapy tolerable toxicities.
futuremedicine.com 
sci-hub.se 参考文章(26)
H. Christiansen, H.A. Wolff, Primäre kurative Radiochemotherapie beim Nasopharynxkarzinom Strahlentherapie Und Onkologie. ,vol. 189, pp. 269- 270 ,(2013) , 10.1007/S00066-012-0285-Y
Christian Michel Zwaan, Bernd Granzen, Lisa Lassay, Peter Deutz, Peter Vorwerk, Gundula Staatz, Günther Gademann, Hans Christiansen, Foppe Oldenburger, Miriam Tamm, Rolf Mertens, Martina Buehrlen, Multimodal treatment, including interferon beta, of nasopharyngeal carcinoma in children and young adults: preliminary results from the prospective, multicenter study NPC-2003-GPOH/DCOG. Cancer. ,vol. 118, pp. 4892- 4900 ,(2012) , 10.1002/CNCR.27395
Weidong Wang, Mei Feng, Zixuan Fan, Jie Li, Jinyi Lang, Clinical Outcomes and Prognostic Factors of 695 Nasopharyngeal Carcinoma Patients Treated with Intensity-Modulated Radiotherapy BioMed Research International. ,vol. 2014, pp. 814948- 814948 ,(2014) , 10.1155/2014/814948
Kuang-Rong Wei, Rong-Shou Zheng, Si-Wei Zhang, Zhi-Heng Liang, Zhu-Ming Li, Wan-Qing Chen, Nasopharyngeal carcinoma incidence and mortality in China, 2013 Chinese Journal of Cancer. ,vol. 36, pp. 90- ,(2017) , 10.1186/S40880-017-0257-9
Ester Orlandi, Stefano Tomatis, Paolo Potepan, Paolo Bossi, Valeria Mongioj, Mauro Carrara, Mauro Palazzi, Marzia Franceschini, Cristiana Bergamini, Laura Locati, Eva Iannacone, Marco Guzzo, Tullio Ibba, Flavio Crippa, Lisa Licitra, Emanuele Pignoli, Carlo Fallai, Critical analysis of locoregional failures following intensity-modulated radiotherapy for nasopharyngeal carcinoma Future Oncology. ,vol. 9, pp. 103- 114 ,(2013) , 10.2217/FON.12.166
Guangli Xiao, Yabing Cao, Xibin Qiu, Weihua Wang, Yufeng Wang, Influence of gender and age on the survival of patients with nasopharyngeal carcinoma BMC Cancer. ,vol. 13, pp. 226- 226 ,(2013) , 10.1186/1471-2407-13-226
G. Fountzilas, E. Ciuleanu, M. Bobos, A. Kalogera-Fountzila, A.G. Eleftheraki, G. Karayannopoulou, T. Zaramboukas, A. Nikolaou, K. Markou, L. Resiga, D. Dionysopoulos, E. Samantas, H. Athanassiou, D. Misailidou, D. Skarlos, T. Ciuleanu, Induction chemotherapy followed by concomitant radiotherapy and weekly cisplatin versus the same concomitant chemoradiotherapy in patients with nasopharyngeal carcinoma: a randomized phase II study conducted by the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation Annals of Oncology. ,vol. 23, pp. 427- 435 ,(2012) , 10.1093/ANNONC/MDR116
Ali Varan, Enis Özyar, Funda Çorapçioğlu, Yavuz Köksal, Burça Aydin, Nalan Yazici, Canan Akyüz, Münevver Büyükpamukçu, Pediatric and young adult nasopharyngeal carcinoma patients treated with preradiation Cisplatin and docetaxel chemotherapy. International Journal of Radiation Oncology Biology Physics. ,vol. 73, pp. 1116- 1120 ,(2009) , 10.1016/J.IJROBP.2008.05.028
Anne W.M. Lee, W.M. Sze, Joseph S.K. Au, S.F. Leung, T.W. Leung, Daniel T.T. Chua, Benny C.Y. Zee, Stephen C.K. Law, Peter M.L. Teo, Stewart Y. Tung, Dora L.W. Kwong, W.H. Lau, Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. International Journal of Radiation Oncology Biology Physics. ,vol. 61, pp. 1107- 1116 ,(2005) , 10.1016/J.IJROBP.2004.07.702
Chan Woo Wee, Bhumsuk Keam, Dae Seog Heo, Myung-Whun Sung, Tae-Bin Won, Hong-Gyun Wu, Locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy plus concurrent weekly cisplatin with or without neoadjuvant chemotherapy. Radiation oncology journal. ,vol. 33, pp. 98- 108 ,(2015) , 10.3857/ROJ.2015.33.2.98