Involucrin Expression in Normal and Neoplastic Human Skin: A Marker for Keratinocyte Differentiation

摘要: Involucrin is a recently recognized structural component of mature squamous epithelial cells. We examined involucrin expression using an immunoperoxidase technique in normal skin and variety epidermal hyperplasias neoplasms to determine whether distinctive staining patterns existed within these lesions. Four reactivity were observed: diffuse intracellular typical keratinocytes the upper third epidermis benign neoplasms; at cell borders, seen principally patchy characteristic carcinoma situ; absence neoplastic basaloid epithelium. Invasive nests carcinomas negative for reactivity, whereas pseudoinvasive tongues epithelium bases keratoacanthomas focally positive. These results suggest that may be useful distinguishing certain from malignant as well understanding altered maturation kinetics proliferative processes afflicting keratinocytes.