Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry
作者： Kun Wang , Liwei Chai , Xinchi Feng , Zhongbo Liu , Hongxia Liu
DOI: 10.1016/J.JPBA.2017.02.038
关键词: Phellodendron chinense 、 Mahonia bealei 、 High-performance liquid chromatography 、 Berberine 、 Glucuronidation 、 Chemistry 、 Coptis chinensis 、 Mass spectrometry 、 Sulfation 、 Chromatography
摘要: … time-of-flight mass spectrometry (UPLC/Q-TOF-MS), and metabolynx™ software with mass defect filter (MDF) technique was developed to investigate the metabolism of BBR. Plasma, …
sci-hub.se 参考文章(25)
Jing‐Yi Ma, Ru Feng, Xiang‐Shan Tan, Chao Ma, Jia‐Wen Shou, Jie Fu, Min Huang, Chi‐Yu He, Shuo‐Nan Chen, Zhen‐Xiong Zhao, Wen‐Yi He, Yan Wang, Jian‐Dong Jiang, Excretion of Berberine and Its Metabolites in Oral Administration in Rats Journal of Pharmaceutical Sciences. ,vol. 102, pp. 4181- 4192 ,(2013) , 10.1002/JPS.23718
Wenguang Wang, Xiaoli Ma, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang, A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case. Journal of Chromatography A. ,vol. 1412, pp. 100- 111 ,(2015) , 10.1016/J.CHROMA.2015.08.015
Hai-Li Shi, Shu-Lin Peng, Jun Sun, Yi-Ming Liu, Yuan-Ting Zhu, Lin-Sen Qing, Xun Liao, Selective extraction of berberine from Cortex Phellodendri using polydopamine-coated magnetic nanoparticles. Journal of Separation Science. ,vol. 37, pp. 704- 710 ,(2014) , 10.1002/JSSC.201301294
Yan Zhou, Shijie Cao, Ying Wang, Peixiang Xu, Jiankun Yan, Wen Bin, Feng Qiu, Ning Kang, Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. Fitoterapia. ,vol. 92, pp. 230- 237 ,(2014) , 10.1016/J.FITOTE.2013.11.010
Xiang-Shan Tan, Jing-Yi Ma, Ru Feng, Chao Ma, Wen-Jing Chen, Yu-Peng Sun, Jie Fu, Min Huang, Chi-Yu He, Jia-Wen Shou, Wen-Yi He, Yan Wang, Jian-Dong Jiang, None, Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats PLoS ONE. ,vol. 8, pp. e77969- ,(2013) , 10.1371/JOURNAL.PONE.0077969
Bo Wen, Mingshe Zhu, Applications of mass spectrometry in drug metabolism: 50 years of progress Drug Metabolism Reviews. ,vol. 47, pp. 71- 87 ,(2015) , 10.3109/03602532.2014.1001029
Yitong Liu, Haiping Hao, Hongguang Xie, Hua Lv, Changxiao Liu, Guangji Wang, Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats Journal of Pharmaceutical Sciences. ,vol. 98, pp. 4391- 4401 ,(2009) , 10.1002/JPS.21721
Bing Pang, Lin-Hua Zhao, Qiang Zhou, Tian-Yu Zhao, Han Wang, Cheng-Juan Gu, Xiao-Lin Tong, Application of Berberine on Treating Type 2 Diabetes Mellitus International Journal of Endocrinology. ,vol. 2015, pp. 905749- 905749 ,(2015) , 10.1155/2015/905749
Yihui Yang, Ning Kang, Hongjun Xia, Jun Li, Lixia Chen, Feng Qiu, Metabolites of protoberberine alkaloids in human urine following oral administration of Coptidis Rhizoma decoction. Planta Medica. ,vol. 76, pp. 1859- 1863 ,(2010) , 10.1055/S-0030-1250053
Yan Li, Hongjie Wang, Nan Si, Wei Ren, Lingyu Han, Shaokun Xin, Ran Zuo, Xiaolu Wei, Jian Yang, Haiyu Zhao, Baolin Bian, Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer Xenobiotica. ,vol. 45, pp. 302- 311 ,(2015) , 10.3109/00498254.2014.979270