Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

作者: Ralf A. Linker , De-Hyung Lee , Sarah Ryan , Anne M. van Dam , Rebecca Conrad

DOI: 10.1093/BRAIN/AWQ386

关键词: Protein nitrosylationMultiple sclerosisExperimental autoimmune encephalomyelitisNeuroinflammationEncephalomyelitisMyelin oligodendrocyte glycoproteinNeuroprotectionMyelinPharmacologyImmunologyBiology

摘要: Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful …

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