Left Ventricular Function Assessed by One-Point Carotid Wave Intensity in Newly Diagnosed Untreated Hypertensive Patients

摘要: Objectives To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1) late systole (W2). Methods A total 145 were compared with age- sex-matched normotensive subjects. They underwent comprehensive echocardiography WI analysis. analysis was performed at level common artery. The diameter changes difference between displacement anterior posterior walls, cursors set to track media-adventitia boundaries 2 cm proximal bulb calibrated systolic diastolic BP. Peak acceleration derived from blood flow velocity measured Doppler sonography range-gate positioned center vessel diameter. based on calculation (dP/dt)×(dU/dt), where dP/dt dU/dt derivatives BP (P) (U) respect time. One-point pulse (PWVβ) interval R ECG first (R-W1), using a high definition echo-tracking system implemented in ultrasound machine (Aloka), also derived. Results After adjustment for body weight, heart rate, physical activity, two groups had similar general characteristics function. However, hypertensives showed significantly LV mass, ejection fraction (LVEF), circumferential end-systolic stress, one-point PWV well W1 (13.646 ± 7.368 vs 9.308 ± 4.675 mmHg m/s3, P =.001) W2 (4.289 ± 2.017 2.995 ± 1.868 =.001). Hypertensives divided into tertiles according LVEF: (11.934 ± 5.836 11.576 ± 5.857 17.227 ± 8.889 <.0001) highest LVEF tertile along relative wall thickness, midwall fractional shortening, endocardial R-W1. Conclusions Newly increased LVM parameters R-W1 values, subjects, but no differences