Genomic signals of selection within and phylogenetic relationships among Strongylocentrotid sea urchins

摘要: The availability of complete genomes allows for direct and powerful tests the different processes underlying molecular evolution quantification their relative contributions. Here, I evaluate contributions natural selection random genetic drift in shaping genome Strongylocentrotid sea urchins using assembled purple urchin, Strongylocentrotus purpuratus by sequencing entire eight additional closely related species. use a phylogenomic approach taking advantage data provided 3,848 nuclear genes to obtain robust well-resolved phylogeny group. observe that synonymous codon usage is biased S. there are five distinct clusters usage. find evidence acts on slightly advantageous mutations through changes bias, involving translational efficiency and/or accuracy as well mRNA folding stability. Finally, comparative genomics group rates non-synonymous substitutions between species detected strong broadly acting purifying extensive signals positive Darwinian (27.6% genes). Sea have long served model organisms key insights into our basic understanding biology will continue furthering role future.