Aspirin, paracetamol and non-steroidal anti-inflammatory drugs. A comparative review of side effects.

摘要: Non-steroidal anti-inflammatory drugs (NSAIDs) effectively control the symptoms of many rheumatic diseases although they have little effect on underlying causes. Their is mainly mediators inflammatory process. Unfortunately, these important physiological roles in maintenance health, particularly gastrointestinal tract and kidney, so that their inhibition results unwanted reactions varying severity. The mechanisms are described. occurrence varies, both qualitatively quantitatively, an attempt made to assess differences, it may be related directly differences dosage therapeutic efficacy. In addition, immunologically mediated adverse occur. These outlined clinical picture. There considerable frequency between compounds: particular there a wide variation rate dermatological this type. Agranulocytosis has been associated with pyrazolone compounds, reported most others. Aplastic anaemia, which not immune-mediated reaction, also thought as but incidence indomethacin approaches similar level. Although all analysed cause hepatic reactions, rare except now withdrawn benoxaprofen. Several types renal occur rarities Paracetamol does any mediators. Anxieties about substance relates parent compound phenacetin its necrotic papillae. extensive literature subject concerning only paracetamol, aspirin other NSAIDs. This assessed summarised. danger paracetamol direct toxin self-poisoning discussed. Novel NSAIDs introduced others frequent monotonous regularity. Sometimes reasons some medical or scientific plausibility, often over-reactions by registration authorities pharmaceutical companies response uninformed media publicity. problems numerically scientifically accurate collection assessment reaction data legion result useful agents lost. Some difficulties described, non-drug 'adverse reactions' described.(ABSTRACT TRUNCATED AT 400 WORDS)