Immunolocalization of a glycosylphosphatidylinositol-specific phospholipase D in mast cells found in normal tissue and neurofibromatosis lesions.
作者： C. N. Metz , P. Thomas , M. A. Davitz
DOI:
关键词: Pathology 、 Phospholipase D 、 Glycan 、 Cell membrane 、 Mast cell 、 Membrane protein 、 Biology 、 Connective tissue 、 Phospholipase 、 Cell biology 、 Glycolipid
摘要: A large number of eukaryotic proteins have been shown to be anchored the cell membrane by glycosylphosphatidylinositol (GPI). This glycolipid anchor can serve as a substrate for anchor-specific phospholipases that convert GPI-anchored into soluble forms. Soluble forms many GPI identified in vivo connective tissue, plasma, and urine. The authors discovered mammalian plasma contains GPI-specific phospholipase D (GPI-PLD). Because it recognizes portion conserved glycan core structure, all are potential substrates. report development murine monoclonal antibody specific one form human GPI-PLD immunohistochemical localization this enzyme mast cells.
参考文章(29)
M A Davitz, J Hom, S Schenkman, Purification of a glycosyl-phosphatidylinositol-specific phospholipase D from human plasma. Journal of Biological Chemistry. ,vol. 264, pp. 13760- 13764 ,(1989) , 10.1016/S0021-9258(18)80065-5
M A Ferguson, M G Low, G A Cross, Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. Journal of Biological Chemistry. ,vol. 260, pp. 14547- 14555 ,(1985) , 10.1016/S0021-9258(17)38603-9
C.N. Metz, Y.Y. Zhang, Y. Guo, T.C. Tsang, J.P. Kochan, N. Altszuler, M.A. Davitz, Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans. Journal of Biological Chemistry. ,vol. 266, pp. 17733- 17736 ,(1991) , 10.1016/S0021-9258(18)55185-1
K S Huang, S Li, W J Fung, J D Hulmes, L Reik, Y C Pan, M G Low, Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase D. Journal of Biological Chemistry. ,vol. 265, pp. 17738- 17745 ,(1990) , 10.1016/S0021-9258(18)38225-5
R C Benyon, M K Church, M A Lowman, Human skin mast cells: their dispersion, purification, and secretory characterization. Journal of Immunology. ,vol. 138, pp. 861- 867 ,(1987)
M G Low, Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors. Biochemical Journal. ,vol. 244, pp. 1- 13 ,(1987) , 10.1042/BJ2440001
M. Ferguson, S. Homans, R. Dwek, T. Rademacher, Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane Science. ,vol. 239, pp. 753- 759 ,(1988) , 10.1126/SCIENCE.3340856
Alan R. Saltiel, Lynn R. Sorbara-Cazan, Inositol glycan mimics the action of insulin on glucose utilization in rat adipocytes. Biochemical and Biophysical Research Communications. ,vol. 149, pp. 1084- 1092 ,(1987) , 10.1016/0006-291X(87)90519-5
Richard L. Stevens, K. Frank Austen, Recent advances in the cellular and molecular biology of mast cells Immunology Today. ,vol. 10, pp. 381- 386 ,(1989) , 10.1016/0167-5699(89)90272-7
N Yoshida, R. Nussenzweig, P Potocnjak, V Nussenzweig, M Aikawa, Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite Science. ,vol. 207, pp. 71- 73 ,(1980) , 10.1126/SCIENCE.6985745