Update on psychotropic medications for cancer-related fatigue.

摘要: Fatigue is a common and highly distressing symptom of cancer associated with reduced quality life considerable psychological functional morbidity. The reported prevalence cancer-related fatigue ranges from 4% to 91%, depending on the specific population studied methods assessment. Cancer-related has typically been underreported, underdiagnosed, undertreated. depression may coexist in patients, overlap symptoms occurs. This partly reason for interest examining role psychotropic medications treating fatigue. Clarifying relationship between necessary effectively evaluate treat Even International Classification Diseases criteria, differentiating difficult. Psychotropic drugs that have include psychostimulants, wakefulness-promoting agents, antidepressants. Methylphenidate most seems be effective well tolerated despite side effects. Some preliminary data support using modafinil less concern about tolerance or dependence. Antidepressant studies shown mixed results. Paroxetine show benefit primarily when it clinical depression. Bupropion, norepinephrine/dopamine reuptake inhibitor, psychostimulant-like effects, therefore more beneficial However, are currently limited. Randomized, placebo-controlled trials agents needed further assess efficacy tolerability treatment