Synthesis and immunostimulant activity of novel analogs of human casein fragment (54-59)
作者： Ragini Sahai , Anju Puri , Ram Prakash Saxena , Rahui Saran , Wahajul Haq
DOI: 10.3109/08923979609052751
关键词: Biology 、 Molecular biology 、 Casein 、 Immunostimulant 、 Phagocytosis 、 Antigenicity 、 Antibody 、 Biochemistry 、 Plasmodium berghei 、 Biological activity 、 Immune system
摘要: AbstractStructural analogs of the hexapeptide sequence 54–59 (A) human casein, reported to stimulate immune response, were synthesized and evaluated for immunostimulant activity. Hexapeptide 91/409 (C), 90/649 (D) 91/361 (E) stimulated higher antibody titre delayed type hvper-sensitivity (DTH) response than natural casein in BALB/c mice-sheep red blood cells (SRBC) guinea pig-ovalbumin models. These peptides also induced stimulation non-specific as evidenced by increase macrophage migration index (MMI), phagocytosis (14C) lecuine labelled Escherchia coli, incorporation (14C)-glucosamine peritoneal macrophages proliferative mouse thymocytes. Significant suppression on course Plasmodium berghei infection was observed day 4, animals treated with hexapeptidse C D.
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