Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes.

摘要: Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy at C-6 position N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction delayed-type hypersensitivity and enhancement antibody production against test protein antigen, ovalbumin, when administered guinea pigs as liposomes, is without mineral oil. When oil-in-water emulsion, including Ribitype emulsions, rather than water-in-mineral oil its 6-O-acyl showed only weak immunoadjuvancies.