Immunomodulation by BCG and Synthetic Bacterial-Like Adjuvants

摘要: Various substances extracted from animal sources and also plants, bacteria, viruses or parasites, have been shown capable of regulating the immune response. However most studied probably strongest exogenous immunomodulators are bacteria their products (25). Attempts at isolating chemically well- defined agents justified timely as they may lead to preparations that retain therapeutic values which required yet cause less toxicity. Indeed although BCG C. parvum be dramatically effective in certain experimental models, investigators well aware fact contain a great variety heterogeneous antigens, some could cross-react host’s tissues (8, 10, 52) produce side effects, even, following dose mode administration, unexpected responses (for instance tumor enhancement instead rejection (54)). The recent development synthetic low molecular weight has renewed interest field adjuvants. What is particularly appealing possibility one can now tailor structure these molecules such way use them effectively influence pre-selected components system. Certain polynucleotides (25), peptide analogs tuftsin (51) thymic factors (34), synthesized because analogy host products. Others produced represent with microbial (11). It our purpose today select this vast arsenal mycobacterial-like These derivatives distributed according classes: a) glycolipids cord factor; b) glycopeptides muramyl peptides; c) glyco-peptidolipids; d) peptidolipids.