Reactivation of streptococcal cell wall-induced arthritis by homologous and heterologous cell wall polymers.

摘要: Joint inflammation initially induced by intraarticular injection of an aqueous suspension peptidoglycan-polysaccharide (PG-PS) fragments isolated from Streptococcus pyogenes was reactivated systemic a normally subarthropathic dose homologous or heterologous cell wall polymers, including muramyl dipeptide and lipopolysaccharide. Reactivation not correlated with the severity initial inflammatory reaction. Results studies utilizing 125I-labeled PG-PS suggested that reactivation associated increased localization in joint following reinjection. These results indicate injury S increases susceptibility to subsequent injury. Furthermore, once reaction is initiated, it can be perpetuated variety ubiquitous polymers derived normal flora as well pathogenic bacteria.