Intramolecular hydrosilylation and silicon-assisted cross-coupling: an efficient route to trisubstituted homoallylic alcohols.
作者： Scott E. Denmark , Weitao Pan
DOI: 10.1021/OL006769Y
关键词: Intramolecular force 、 Aryl 、 Organic chemistry 、 Chemistry 、 Combinatorial chemistry 、 Stereoselectivity 、 Halide 、 Silicon 、 Catalysis 、 Hydrosilylation 、 Palladium
摘要: Alkylidenesilacyclopentanes (formed by intramolecular hydrosilylation of homopropargyl alcohols) are efficiently coupled with aryl or alkenyl halides in the presence tetrabutylammonium fluoride and a palladium(0) catalyst. Yields cross-coupling were generally high, reaction is compatible wide range functional groups. The overall transformation achieves conversion alcohols to trisubstituted homoallylic highly stereoselective fashion.
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