No Effect of Anodal Transcranial Direct Current Stimulation on Gamma-Aminobutyric Acid Levels in Patients with Recurrent Mild Traumatic Brain Injury
作者： Skadi Wilke , Jonathan List , Ralf Mekle , Robert Lindenberg , Martin Bukowski
关键词: gamma-Aminobutyric acid 、 Primary motor cortex 、 Transcranial magnetic stimulation 、 Traumatic brain injury 、 Concussion 、 Anesthesia 、 Transcranial direct-current stimulation 、 In vivo magnetic resonance spectroscopy 、 Motor cortex 、 Psychology
摘要: Abstract In patients in the chronic phase after recurrent mild traumatic brain injury (mTBI), alterations gamma-aminobutyric acid (GABA) concentration and receptor activity have been reported, possibly mediating subtle but persistent cognitive deficits increased rate of dementia older age. We evaluated whether anodal transcranial direct current stimulation (atDCS) over primary motor cortex reduces GABA GABAB with mTBI. Seventeen (mean age 25, two women) mTBI 22 healthy control subjects 26, were included. All participants received comprehensive testing detailed questionnaires on post-concussive symptoms at baseline. Subsequently, they participated four experimental sessions, consisting either magnetic resonance spectroscopy (MRS)/atDCS/MRS, (TMS)/atDCS/TMS, MRS/sham/MRS, or TMS/sham/TMS to determine concentr...
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