Pharmacologic approaches to cerebral aging and neuroplasticity: insights from the stroke model.

摘要: Brain plasticity is an intrinsic characteristic of the nervous system that allows continuous remodeling brain functions in pathophysiological conditions. Although normal aging associated with morphological modifications and decline cerebral functions, at least partially preserved elderly individuals. A growing body evidence supports notion cognitive enrichment aerobic training induce a dynamic reorganization higher thereby helping to maintain operational skills reducing incidence dementia. The stroke model clearly shows spontaneous exists after lesion, even old patients, it can be modulated through external factors like rehabilitation drugs. Whether drugs used aim modulating effects physical or stimulation healthy aged people has not been addressed until now. risk:benefit ratio will key question regard ethical aspect this challenge. We review article main aspects human as shown patients stroke, drug modulation its consequences on recovery, finally we address influence plasticity.