Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or dna methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions
作者： Francis Barany , Sunggook Park , Steven A. Soper , John William Efcavitch
DOI:
关键词: Nuclease 、 DNA methylation 、 Biochemistry 、 Nucleic acid 、 Polymerase 、 DNA ligase 、 Nucleotide 、 Chemistry 、 Nucleic acid sequence 、 Terminal deoxynucleotidyl transferase
摘要: The present invention is directed methods for identifying, in a sample, one or more target nucleotide sequences differing from other the sample by nucleotides, copy numbers, transcript sequences, and/or methylated residues, using ligation detection reactions, polymerase mediated extension cleavage reactions. also to nucleotides sequence.
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