Growth differentiation factor 15 (gdf-15) constructs
作者： Agnes Eva Hamburger , Yumei Xiong , Jackie Zeqi Sheng , Zhulun Wang , Kenneth William Walker
DOI:
关键词: Mutant 、 Type 2 diabetes 、 Internal medicine 、 Elevated insulin 、 GDF15 、 Diabetic nephropathy 、 Obesity 、 Endocrinology 、 Metabolic disorder 、 Dyslipidemia 、 Biology
摘要: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs thereof, can be of use in treatment or ameliorating a metabolic disorder. disease disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, insulin levels diabetic nephropathy.
lens.org参考文章(61)
H. Michael Shepard, Irene Ni, Pei Jin, Hepatocyte growth factor intron fusion proteins ,(2006)
Yasuo Sugiyama, Asae Shintani, Masatoshi Hazama, Tgf-beta superfamily production/secretion promoter ,(2002)
Gregory Alan Lazar, Fc polypeptides with novel Fc ligand binding sites ,(2004)
Nigel John Watkins, King-Ming Lo, Stephen D Gillies, Matthew Paul Baker, Fc-interferon-beta fusion proteins ,(2005)
Alfonso R. Gennaro, Remington: The Science and Practice of Pharmacy ,(2003)
Herbert Herzog, Shu Lin, Samuel Norbert Breit, David Alexander Brown, Agents and methods for modulating macrophage inhibitory cytokine (mic-1) activity ,(2008)
Asne Rhoda Bauskin, Samuel Norbert Breit, Method for Modulating Appetite ,(2005)
Agnes Eva Hamburger, Bryan Lemon, Yumei Xiong, Jackie Zeqi Sheng, Zhulun Wang, Kenneth W. Walker, Murielle Veniant-Ellison, Gunasekaran Kannan, Yi Zhang, Jie Tang, Grant Shimamoto, Xiaoshan Min, Growth differentiation factor 15 (gdf-15) polypeptides ,(2013)
Jim H. Kou, Andreas W. Supersaxo, Controlled delivery of pharmaceuticals from preformed porous microparticles ,(1993)
Judy Y. Chang, Nancy C. McFarland, James R. Swartz, Method for refolding insoluble, misfolded insulin-like growth factor-1 into an active conformation ,(1991)