Fatty acids and their use in conjugation to biomolecules
作者： Chikwendu Ibebunjo , Louise Clare Kirman , David Weninger Barnes , Aimee Richardson Usera , Changgang Lou
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摘要: The invention provides a conjugate comprising biomolecule linked to fatty acid via linker wherein the has following Formulae A1, A2 or A3: R1, R2, R3, R4, Ak, n, m and p are defined herein. also relates method for manufacturing of such as GDF15 conjugate, its therapeutic uses treatment prevention metabolic disorders diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic nonalcoholic liver disease/steatohepatitis other progressive insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial stroke, heart failure, coronary diabetic complications (including but not limited chronic kidney disease), neuropathy, gastroparesis disorders. present further combination pharmacologically active agents pharmaceutical composition.
lens.org 参考文章(111)
Kazuhiko Tatemoto, Yugo Habata, Masaki Hosoya, Shuji Hinuma, Ryo Fujii, Chieko Kitada, APJ ligand polypeptides ,(1999)
Aimee Usera, Jennifer Cobb, Zachary Robinson, Site-specific chemoenzymatic protein modifications ,(2014)
C Delgado, G E Francis, D Fisher, The uses and properties of PEG-linked proteins. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 9, pp. 249- 304 ,(1992)
Jeffrey T.L. Smith, Brian Baker, John A. Latham, Regulation of glucose metabolism using anti-cgrp antibodies ,(2014)
Kjeld Madsen, Florencio Zaragoza Dorwald, Thomas Kruse Hansen, Nils Langeland Johansen, Paw Bloch, Jesper Lau, Albumin-binding conjugates comprising fatty-acid and peg ,(2012)
Victor Tuan Giam Chuang, Ulrich Kragh‐Hansen, Masaki Otagiri, Pharmaceutical Strategies Utilizing Recombinant Human Serum Albumin Pharmaceutical Research. ,vol. 19, pp. 569- 577 ,(2002) , 10.1023/A:1015396825274
Robert K. Scopes, Protein Purification: Principles and Practice ,(1982)
Hsien-Po Chiu, Tetsuo Uno, Weijia Ou, Bernhard Geierstanger, Jan Grunewald, Xueshi Hao, Tiffany Crossgrove, Susan E. Cellitti, Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues ,(2009)
Michael Jackson, Mark Erlander, Per Peterson, Shaoming Huang, Tnf-beta-like protein for treating prostate cancer, and related nucleic acid molecules, pharmaceutical compositions and methods ,(1997)
Haeshin Lee, Il Ho Jang, Sung Ho Ryu, Tae Gwan Park, N-terminal site-specific mono-PEGylation of epidermal growth factor. Pharmaceutical Research. ,vol. 20, pp. 818- 825 ,(2003) , 10.1023/A:1023402123119