Maternal Alcohol Consumption before and during Pregnancy and the Risks of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis.
作者： Jian Sun , Xiaoling Chen , Huajun Chen , Zhengliang Ma , Jianwei Zhou
DOI: 10.1111/CHD.12271
关键词: Offspring 、 Cohort study 、 Medicine 、 MEDLINE 、 Meta-analysis 、 Obstetrics 、 Confidence interval 、 Pregnancy 、 Publication bias 、 Relative risk
摘要: Objective Epidemiologic studies have reported conflicting results regarding maternal alcohol consumption before and during pregnancy, the risk of congenital heart defects (CHDs). However, a systematic review meta-analysis association between CHDs in offspring has not been conducted. Design We searched MEDLINE EMBASE for articles catalogued their inception February 16, 2015; we identified relevant published that assessed CHD risk. Two authors independently eligibility retrieved extracted data from them. Study-specific relative estimates were pooled by random-effects or fixed-effects models. Results From 1527 references, total 19 case–control four cohort enrolled this meta-analysis. The summary 23 related to indicated an overall 1.13 (95% confidence interval: 0.96, 1.29) among mothers drinking pregnancy. Statistically significant heterogeneity was detected (Q = 196.61, P < .001, I2 88.8%) with no publication bias (Egger's test: .157). We conducted stratified meta-regression analyses identify origin studies. Conclusion In summary, provided positive CHDs.
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