Effect of Ginseng (Panax ginseng) Berry EtOAc Fraction on Cognitive Impairment in C57BL/6 Mice under High-Fat Diet Inducement
作者： Chang Hyeon Park , Seon Kyeong Park , Tae Wan Seung , Dong Eun Jin , Tianjiao Guo
DOI: 10.1155/2015/316527
关键词: Malondialdehyde 、 Type 2 diabetes 、 Endocrinology 、 In vivo 、 Ex vivo 、 Medicine 、 Ginseng 、 Ginsenoside 、 Traditional medicine 、 Diabetes mellitus 、 Morris water navigation task 、 Internal medicine
摘要: High-fat diet-induced obesity leads to type 2 diabetes. Recently, there has been growing apprehension about diabetes-associated cognitive impairment (DACM). The effect of ginseng (Panax ginseng) berry ethyl acetate fraction (GBEF) on mice with high-fat was investigated confirm its physiological function. C57BL/6 were fed a diet for 5 weeks and then GBEF (20 50 mg/kg body weight) 4 weeks. After three in vivo behavioral tests (Y-maze, passive avoidance, Morris water maze tests), blood samples collected from the postcaval vein biochemical analysis, whole brains prepared an ex test. A method based ultra-performance liquid chromatography (UPLC) accurate-mass quadrupole time-of-flight mass spectrometry (Q-TOF/MS) used determine major ginsenosides. decreased fasting glucose levels diabetes mellitus (DM) improved hyperglycemia. Cognitive behavior examined after setting up DM mice. experiments showed that treated exhibited more than In addition, effectively inhibited acetylcholinesterase (AChE) activity malondialdehyde (MDA) brain tissues. Q-TOF UPLC/MS analyses ginsenoside Re ginsenoside.
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