Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS.
作者： Liang Yang , Yuguang Wang , Guangyao Huang , Jian Li , Zhaoyan Zhang
DOI: 10.1155/2018/6527549
关键词:
摘要: Objectives. To investigate whether Panax ginseng (P. ginseng) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo. Methods and Results. 24 male Sprague-Dawley rats were randomized for 7-day treatment with P. (low, middle, high), or vehicle. was administered orally to each group on 8th day. Plasma samples collected, Xevo TQ-S used detect concentration aconitine, mesaconitine, hypaconitine plasma. We describe a fast reproducible method Compared control group, three DAs increased both middle high dosing groups. The Vz/F these groups as well CLz/F aconitine all mesaconitine decreased compared group. Conclusion. Orally administrated potentially inhibits rats.
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