Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer

摘要: Myeloid-derived suppressor cells (MDSCs) have been identified in the majority of patients and experimental mice with tumors by their suppression T cell activation. MDSCs also reported to be associated chronic inflammation. In advanced cancer, helper (Th) balance tends shift from Th1 Th2 predominance, immune function, including cell-mediated immunity, is impaired cytokines produced cells. The present study examined correlations between MDSC levels inflammation, suppression, malnutrition, poor prognosis 155 breast cancer. preoperative recurrent cancer were significantly higher compared postoperative patients, who received chemotherapy healthy volunteers. positively correlated interleukin (IL)-6 production peripheral blood mononuclear (PBMCs), neutrophil/lymphocyte ratio C-reactive protein, negatively interferon-γ IL-12, serum concentration rapid turnover stimulation index. These divided into two groups based on MDSCs. >1.0% total PBMCs, overall survival stage IV disease was shorter other stages, <1.0% PBMCs. Thus, may function as a good prognostic indicator, particularly