Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy.

摘要: Background: Intravenous infusion of lidocaine decreases postoperative pain and speeds the return bowel function. The authors therefore tested hypothesis that perioperative facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. Methods: Forty scheduled to undergo colectomy were randomly allocated receive intravenous (bolus injection 1.5 mg/kg at induction anesthesia, then a continuous 2 mg kg 1 h intraoperatively 1.33 for 24 postoperatively) or an equal volume saline. All received similar intensive rehabilitation. Postoperative scores, opioid consumption, fatigue scores measured. Times first flatus, defecation, hospital discharge recorded. endocrine (cortisol catecholamines) metabolic (leukocytes, C-reactive protein, glucose) responses measured 48 h. Data (presented as median [25‐75% interquartile range], vs. saline groups) analyzed using Mann‐Whitney tests. P < 0.05 was considered statistically significant. Results: Patient demographics two groups. flatus (17 [11‐24] 28 [25‐33] h; 0.001), defecation (28 [24‐37] 51 [41‐70] (2 [2‐3] 3 [3‐4] days; 0.001) significantly shorter who lidocaine. Lidocaine reduced consumption (8 [5‐18] 22 [14‐36] mg; 0.005) scores. In contrast, Conclusions: improves analgesia, fatigue, function after These benefits are associated with significant reduction stay.