Immunosuppressory activity of the cyclodimeric peptide with RGD-sequences.
作者： Z Szewczuk , P Buczek , P Stefanowicz , K Krajewski , Z Wieczorek
关键词: Integrin 、 Immune system 、 Biology 、 Chemical synthesis 、 T cell 、 Cell biology 、 Cell 、 Sequence (biology) 、 MHC class II 、 Biochemistry 、 Peptide
摘要: Our previous studies showed that the nonapeptide fragment of HLA-DQ sequence H-Thr-Pro-Gln-Arg-Gly-Asp-Val-Tyr-Thr-OH, located in 164–172 loop, strongly suppresses humoral and cellular immune responses, while its shorter analogs, H-Arg-Gly-Asp-Val-OH, H-Arg-Gly-Asp-Val-Tyr-OH H-Gln-Arg-Gly-Asp-Val-Tyr-OH show only a weak stimulatory activity respect to immunological response. These fragments contain Arg-Gly-Asp (RGD) sequence, known for importance association phenomena. Based on crystal structure HLA-DR1, we also designed synthesized cyclic analog H-Cys-Arg-Gly-Asp-Val-Tyr-Cys-OH with restricted conformation, which response selectively inhibits v3 integrin, suggesting mechanism immunosuppressory action peptide is associated inhibition integrin. In this paper present design synthesis cyclodimeric peptide, Arg-Gly-Asp-Arg-Gly-Asp , as selective inhibitor. The both results support our hypothesis immunomodulatory may be connected their interactions some particular integrins cell surface.
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