Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma
作者： M.D. Siegelin , A. Habel , T. Gaiser
DOI: 10.1016/J.NEULET.2008.10.036
关键词: Biology 、 Tumor necrosis factor alpha 、 Survivin 、 Programmed cell death 、 Protein kinase B 、 Glioma 、 Cell culture 、 Cytotoxicity 、 Internal medicine 、 Endocrinology 、 Apoptosis 、 Cancer research
摘要: EGCG is a flavonoid that exhibited therapeutic activity in cancer. In this study three glioblastoma cell lines (U87, A172 and U251) were treated with EGCG, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or the combination of both. Treatment subtoxic doses TRAIL induces rapid apoptosis TRAIL-resistant glioma cells, suggesting combined treatment may offer an attractive strategy for treating gliomas. down-regulated phosphoprotein-enriched astrocytes (PEA15) through Akt (PKB)-dependent mechanism. addition, over-expression PEA15 attenuated cytotoxicity induced by TRAIL. summary, key regulator TRAIL-EGCG-mediated death malignant glioma.
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