Natural Polyphenols Target the Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling Pathway for Cancer Chemoprevention

摘要: Polyphenols, occurring in vegetables, fruits, seeds, grains, herbs, spices, propolis, tea, beer, and wine, play a significant role cancer chemoprevention. Natural polyphenols exert anticancer chemopreventive properties by multiple mechanisms of action affecting apoptotic pathways cells. The induction cell-specific apoptosis via the activation TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) signaling has become an important focus research. Targeting TRAIL-mediated pathway cells polyphenolic compounds could be one responsible for their activity. Death ligand is member TNF factor) superfamily. Endogenous potent agent capable inducing without toxicity to normal Soluble or expressed on immune cells, takes part surveillance defense against However, as more tumor are reported resistant death, it necessary develop new strategies overcome this resistance. Polyphenols have been shown sensitize TRAIL-induced apoptosis. This chapter describes natural that were found enhance provides overview molecular targets underlying reversal TRAIL-resistance