Photoinduced antibacterial activity of two dicationic 5,15-diarylporphyrins.
作者： Viviana T. Orlandi , Enrico Caruso , Gianluca Tettamanti , Stefano Banfi , Paola Barbieri
DOI: 10.1016/J.JPHOTOBIOL.2013.08.011
关键词: Antibacterial activity 、 Photochemistry 、 Bacteria 、 Visible spectrum 、 Lipophilicity 、 Substituent 、 Stereochemistry 、 Cationic polymerization 、 Antimicrobial 、 Singlet oxygen 、 Chemistry
摘要: Antimicrobial photodynamic treatment combines the use of photosensitizers (PSs) and visible light to kill bacterial cells. Cationic porphyrins are PSs largely used against bacteria and, among them, those featuring one positive charge on each 5,10,15,20-tetraaryl substituent (tetracationic) most used. The aim this study was synthesize two dicationic 5,15-di(N-alkyl-4-pyridyl)porphyrins, bearing methyl (PS 3) benzyl 4) N-alkylating groups, compare efficiency in antibacterial treatment, upon irradiation with a halogen-tungsten white lamp. killing PS 4 constantly found higher than that 3 both pure mixed cultures laboratory model microorganisms as well wild wastewater microflora. comparable regards singlet oxygen generation, but show different repartition coefficient; more lipophilic benzylated shows better interaction cells methylated 3). data support hypothesis an efficient PS-cell binding is required obtain significant effects. A correlation cell binding, photoinactivation lipophilicity suggested.
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