Psychosocial factors and disease progression in simian AIDS: a preliminary report.

摘要: Infection of macaques by the simian immunodeficiency virus (SIV), like HIV infection in humans, results a variable time course to clinical disease. Developmental studies have shown that psychosocial disruption, including social separations, can result both immediate and long-term immunological consequences. Using colony records on subset rhesus (Macaca mulatta) inoculated with SIV at California Primate Research Center, Davis, California, USA, we constructed regression equations determine whether animals' histories could explain any variability observed measures disease progression. After controlling for dosage, age inoculation, sex, previous inoculation history, variables were found be significantly associated several indicators disease, latencies display leukopenia lymphopenia, weight loss, survival. We believe these preliminary suggest an important role processes affecting progression macaques.