Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
作者： Harri M. Itkonen , Saurabh S. Gorad , Damien Y. Duveau , Sara E.S. Martin , Anna Barkovskaya
关键词: Biochemistry 、 Cancer research 、 Glycolysis 、 Prostate 、 Programmed cell death 、 Medicine 、 Prostate cancer 、 Cyclin-dependent kinase 1 、 Viability assay 、 Enzyme 、 Cell growth
摘要: Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We …
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John A. Hanover, Michael W. Krause, Dona C. Love, Bittersweet memories: linking metabolism to epigenetics through O -GlcNAcylation Nature Reviews Molecular Cell Biology. ,vol. 13, pp. 312- 321 ,(2012) , 10.1038/NRM3334
Charles E Massie, Andy Lynch, Antonio Ramos-Montoya, Joan Boren, Rory Stark, Ladan Fazli, Anne Warren, Helen Scott, Basetti Madhu, Naomi Sharma, Helene Bon, Vinny Zecchini, Donna-Michelle Smith, Gina M DeNicola, Nik Mathews, Michelle Osborne, James Hadfield, Stewart MacArthur, Boris Adryan, Scott K Lyons, Kevin M Brindle, John Griffiths, Martin E Gleave, Paul S Rennie, David E Neal, Ian G Mills, The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis The EMBO Journal. ,vol. 30, pp. 2719- 2733 ,(2011) , 10.1038/EMBOJ.2011.158
Robert H. Costa, FoxM1 dances with mitosis. Nature Cell Biology. ,vol. 7, pp. 108- 110 ,(2005) , 10.1038/NCB0205-108
Mark A Preston, Anders H Riis, Vera Ehrenstein, Rodney H Breau, Julie L Batista, Aria F Olumi, Lorelei A Mucci, Hans-Olov Adami, Henrik T Sørensen, None, Metformin Use and Prostate Cancer Risk European Urology. ,vol. 66, pp. 1012- 1020 ,(2014) , 10.1016/J.EURURO.2014.04.027
Gerald W. Hart, Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism. Frontiers in Endocrinology. ,vol. 5, pp. 183- 183 ,(2014) , 10.3389/FENDO.2014.00183
Hannelore Heemers, Frank Vanderhoydonc, Tania Roskams, Ishaiahu Shechter, Walter Heyns, Guido Verhoeven, Johannes V. Swinnen, Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo Molecular and Cellular Endocrinology. ,vol. 205, pp. 21- 31 ,(2003) , 10.1016/S0303-7207(03)00205-3
H M Itkonen, N Engedal, E Babaie, M Luhr, I J Guldvik, S Minner, J Hohloch, M C Tsourlakis, T Schlomm, I G Mills, UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N -linked glycosylation Oncogene. ,vol. 34, pp. 3744- 3750 ,(2015) , 10.1038/ONC.2014.307
Benjamin J. Gross, Brian C. Kraybill, Suzanne Walker, Discovery of O-GlcNAc Transferase Inhibitors Journal of the American Chemical Society. ,vol. 127, pp. 14588- 14589 ,(2005) , 10.1021/JA0555217
Sarah J Ross, Susan E Critchlow, Emerging approaches to target tumor metabolism. Current Opinion in Pharmacology. ,vol. 17, pp. 22- 29 ,(2014) , 10.1016/J.COPH.2014.07.001
Stella M. Ranuncolo, Salil Ghosh, John A. Hanover, Gerald W. Hart, Brian A. Lewis, Evidence of the Involvement of O-GlcNAc-modified Human RNA Polymerase II CTD in Transcription in Vitro and in Vivo Journal of Biological Chemistry. ,vol. 287, pp. 23549- 23561 ,(2012) , 10.1074/JBC.M111.330910