6. Cathepsin K inhibitors: their potential as anti-osteoporosis agents.

摘要: Publisher Summary Since the discovery of cathepsin K, its critical role in resorption organic matrix bone has been established by efforts numerous research groups. The potential use K inhibitors to prevent and treat osteoporosis spurred drug at many pharmaceutical companies. Pathological roles arthritis atherosclerosis offer other therapeutic options. Many thiol reactive groups have coupled with enzyme recognition sequences devise potent inhibitors. Multiple cycles design, synthesis, structure elucidation, property profiling proved fruitful. These are paying off entering clinical studies. Early human data supports a promising future for this class drugs.