Risk factors of duodenal ulcer bleeding: the role of smoking and nicotine.

摘要: Several studies have shown that cigarette smoking affects duodenal ulcer (DU) recurrence. To verify any correlation between and complications of disease, we studied 33 DU smokers, 16 ex-smokers 87 non-smokers for up to 48 months, recording age, sex, family history ulcer, symptoms, non-steroidal anti-inflammatory drug use, length history, alcohol consumption, habit, relapses bleeding episodes. Nicotine contents were also obtained the type cigarettes smoked. Statistics used were: Analysis variance with Bonferroni's test. Pearson's chi-squared test stepwise logistic regression analysis. Smokers found significantly more but fewer episodes than (63.3%, 31.2% 34.5%, p = 0.029; 12.1%, 43.7% 0.017). Bleeders often males non-bleeders (82.9% vs. 61.0%, 0.01) had symptoms less frequently (9.7% 26.3%, 0.02). Multivariate analysis confirmed sex as a risk factor (OR 3.0) "protective" 0.4) bleeding, while nicotine intake was be unrelated this complication. We concluded (but not intake) male are factors take into account in evaluating bleeding.