Influence of Methods Used to Establish Sarcopenia Cutoff Values for Skeletal Muscle Measures Using Unenhanced and Contrast‐Enhanced Computed Tomography Images

摘要: BACKGROUND Multiple cutoff values of computed tomography (CT)-based skeletal muscle measures have been proposed, but there is currently no consensus used to identify sarcopenia. We aimed evaluate the influence statistical methods establish sarcopenia and examine impact contrast enhancement on measures. METHODS The area (SMA) radiation attenuation (MRA) 316 healthy individuals were measured unenhanced CT images at third lumbar vertebra level, index (SMI) was SMA divided by height squared. Possible established using 2 methods: 5th percentile aged 20-60 years or mean - 2 × SD 20-50 years. concordance assessed Cohen's κ coefficients McNemar test. parameters 3 phases from 30 examinations compared. RESULTS between almost perfect (κ coefficients: 0.830-0.849) for low MRA slight moderate 0.189-0.591) SMI, especially in men (P < 0.01). Compared with images, SMA, contrast-enhanced increased 0.8%-1.7%, 0.8%-1.8%, 14.8%-21.6% (all P 0.001), respectively, only changes clinically significant. CONCLUSIONS establishing identification SMI MRA, respectively. Thus, definition should include standardized method phase analysis.