A Systematic Review of Esophageal MicroRNA Markers for Diagnosis and Monitoring of Barrett's Esophagus.

摘要: Esophageal epithelial microRNAs may be used to diagnose Barrett’s esophagus (BE) and possibly monitor its progression esophageal adenocarcinoma (EAC). We reviewed studies that have investigated this identify with high biomarker potential for screening disease monitoring in BE. PubMed EMBASE databases were searched quantified microRNAs. Publications reporting microRNA comparisons of normal, non-dysplastic BE, BE high-grade dysplasia (HGD), EAC tissues using both unbiased discovery independent validation phases reviewed. Eleven on expression differences between normal epithelium (seven studies), HGD (4) or (7), (3) (6) identified, the findings their phase analyzed. Increased miR-192, -194, -215, reduced miR-203 -205 compared was noticed by all 4–6 seven examined these In heterogeneity tests reported fold-change values, I 2 statistics 7.9–17.1 % (all P < 0.05). Elevated diminished levels also noted against normal. contrast, a consistent difference absent MicroRNAs -203, -205, -215 are promising tissue biomarkers diagnosing Cross-sectional data suggest limited role separating from HGD/EAC epithelia but need further testing longitudinal follow-up studies.