Genomic profiles specific to patient ethnicity in lung adenocarcinoma.

摘要: Purpose: East-Asian (EA) patients with non–small-cell lung cancer (NSCLC) are associated a high proportion of nonsmoking women, epidermal growth factor receptor ( EGFR )-activating somatic mutations, and clinical responses to tyrosine kinase inhibitors. We sought identify novel molecular differences between NSCLCs from EA Western European (WE) patients. Experimental Design: A total 226 adenocarcinoma samples n = 90) WE 136) were analyzed for copy number aberrations (CNA) by using common high-resolution SNP (single nucleotide polymorphism) microarray platform. Univariate multivariate analyses carried out CNAs specifically related smoking history, mutation status, ethnicity. Results: The overall genomic profiles adenocarcinomas highly similar. revealed several significantly ethnicity, mutation, smoking, but not gender, KRAS or p53 mutations. model identified four ethnic-specific recurrent CNAs—significantly higher rates gain observed on 16p13.13 16p13.11 in tumors, whereas loss 19p13.3 19p13.11 tumors potential driver genes these regions, showing positive correlation cis-localized changes transcriptomic changes. Conclusion: 16p gains 19p losses chromosomal adenocarcinoma. Patient ethnicity should be considered when evaluating future NSCLC therapies targeting located areas. Clin Cancer Res; 17(11); 3542–50. ©2011 AACR .