The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers

摘要: Purpose: Recent studies reported that clinical responsiveness to gefitinib was associated with somatic mutation of epidermal growth factor receptor ( EGFR ) gene in non–small cell lung cancers (NSCLC). Here, we investigated the relationship between and clinicopathologic features. Experimental Design: mutational status 120 NSCLCs determined mainly exons 18 21 by direct sequence correlated parameters. Results: mutations were present 38 cases (32%) majority in-frame deletions exon 19 (19 cases) a missense (18cases). frequently adenocarcinoma P = 0.0001). Of interest, increasing smoke exposure inversely related rate 0.01) dominance for males females. Twenty-one treated found significantly 0.002). In addition, median survival times patients without 25.1 14.0 months, respectively. Patients had approximately 2-fold advantage; however, difference not significant. Conclusions: We show histology strong predictive NSCLC.