Human red blood cell polymorphisms and malaria.

摘要: Genetic factors are a major determinant of child survival in malaria endemic countries. Identifying which genes involved and how they affect the disease risk potentially offers powerful mechanism through to learn more about host-parasite relationship. The past few years have seen significant progress towards achieving this goal for some best-known resistance that determine structure or function red blood cells: Gerbich group antigen negativity; polymorphisms complement receptor (most notably CR1); Southeast Asian ovalocytosis; pyruvate kinase deficiency; haemoglobin E; sickle cell trait; alpha-thalassaemia all examples. challenge future must be translate such advances into fresh approaches prevention treatment malaria.