Chemistry of drug allergenicity.

摘要: Of the very large number and variety of drugs used in medicine, those that are frequently implicated immediate allergic reactions relatively small include neuromuscular blocking anaesthesia, beta-lactam antibiotics, some other antibacterial agents including broad-spectrum antibiotics quinolones and, less often, narcotics. Structure-activity immunochemical investigations have been most numerous detailed for beta-lactams, particularly penicillins. For former group drugs, morphine is proving to be a useful agent in-vitro detection clinically relevant drug-- as well morphine- fentanyl-reactive IgE antibodies. The employment so-called 'major' 'minor' determinants range different penicillins cephalosporins has revealed previously unsuspected heterogeneity patient recognition responses, reinforced findings on allergenic importance side-chain groups. Many reports published anaphylaxis chlorhexidine, progress identifying reviewed together with still inadequately understood subject antibody quinolone agents.