Identification of penicillin allergenic determinants that bind IgE antibodies in the sera of subjects with penicillin allergy.

摘要: Abstract Much of the literature on penicillin hypersensitivity is devoted to identification antigens rather than allergens. Human IgE-binding determinants different penicillins have rarely been closely investigated with view defining fine structural allergenic features and differences. We developed radioimmunoassays employing ampicillin, amoxicillin ticarcillin solid phases for detection penicillin-reactive IgE antibodies. Quantitative hapten inhibition studies employed identify regions molecules revealed a heterogeneous group consisting exclusively, or in part, α-aminobenzyl benzyl side chain groups β-lactam thiazolidine rings nucleus.