Enhancement of solubility, dissolution rate and bioavailability of atorvastatin using solid lipid: in vitro and in vivo characterization

摘要: The objective of present investigation was to enhance solubility, dissolution rate and bioavailability poorly water soluble drug atorvastatin using solid lipid glycerol monostearate surfactant poloxamer-407. Oral pastilles poloxamer were formulated by pastillation technique optimized central composite design. Hemispherical evaluated for content, saturation solubility study, thermal properties in vitro, ex vivo release study. Formulation F4 at high level (1000 mg) poloxamer-407 (400 showed 25-fold 3-fold increased rate, respectively. X-Ray diffraction scanning electron microscopic study proved the decrease crystallinity confirmed conversion crystalline amorphous form, Ex revealed that maximum amount released absorbed through everted intestine. In rats higher HMG CoA mevalonate ratio than plain drug. This indicated better hyperlipidemic activity atorvastatin. Thus, enhanced successfully carrier system.