Properties of the outward currents in frog atrial muscle.

作者: A. de Hemptinne

DOI: 10.1007/BF00588003

关键词: Giant axonSucrose gapRectificationVoltage clampBiophysicsSquidHodgkin–Huxley modelAnatomyElectrophysiologyMembrane potentialChemistry

摘要: The technique of the double sucrose gap was used to perform voltage clamp experiments on small segments isolated auricular trabeculae frog heart. dependence and kinetics delayed rectification current were analyzed. total outward could be dissociated into two components: one component is defined as leakage (Il) shows inward rectification; a second (IK). activation ofIKcan described by Hodgkin Huxley type kinetical model. rate constants are found smaller factor about 103 than those in giant axon squid.

参考文章(15)
Hilary F. Brown, Susan J. Noble, A quantitative analysis of the slow component of delayed rectification in frog atrium The Journal of Physiology. ,vol. 204, pp. 737- 747 ,(1969) , 10.1113/JPHYSIOL.1969.SP008941
A. L. Hodgkin, A. F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve The Journal of Physiology. ,vol. 117, pp. 500- 544 ,(1952) , 10.1113/JPHYSIOL.1952.SP004764
O. Rougier, G. Vassort, R. St�mpfli, Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique. Pflügers Archiv: European Journal of Physiology. ,vol. 301, pp. 91- 108 ,(1968) , 10.1007/BF00362729
A. L. Hodgkin, A. F. Huxley, Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo The Journal of Physiology. ,vol. 116, pp. 449- 472 ,(1952) , 10.1113/JPHYSIOL.1952.SP004717
Hilary F. Brown, Susan J. Noble, Membrane currents underlying delayed rectification and pace-maker activity in frog atrial muscle The Journal of Physiology. ,vol. 204, pp. 717- 736 ,(1969) , 10.1113/JPHYSIOL.1969.SP008940
A. L. Hodgkin, A. F. Huxley, The components of membrane conductance in the giant axon of Loligo The Journal of Physiology. ,vol. 116, pp. 473- 496 ,(1952) , 10.1113/JPHYSIOL.1952.SP004718
Fred J. Julian, John W. Moore, David E. Goldman, Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique. The Journal of General Physiology. ,vol. 45, pp. 1195- 1216 ,(1962) , 10.1085/JGP.45.6.1195
O. Rougier, G. Vassort, Y. M. Gargouil, E. Coraboeuf, Existence and role of a slow inward current during the frog atrial action potential. Pflügers Archiv: European Journal of Physiology. ,vol. 308, pp. 91- 110 ,(1969) , 10.1007/BF00587018
G. W. Beeler, H. Reuter, Voltage clamp experiments on ventricular myocardial fibres The Journal of Physiology. ,vol. 207, pp. 165- 190 ,(1970) , 10.1113/JPHYSIOL.1970.SP009055