Role of aldehydes in fructose induced hypertension.
作者： Sudesh Vasdev , Carol Ann Ford , Linda Longerich , Veeresh Gadag , S. Wadhawan
关键词: Clinical chemistry 、 Platelet 、 Cysteine 、 Endocrinology 、 Fructolysis 、 Blood pressure 、 Lipid peroxidation 、 Kidney 、 Fructose 、 Biochemistry 、 Chemistry 、 Internal medicine
摘要: Aldehydes are formed in tissues of humans and animals as intermediates glucose fructose metabolism due to lipid peroxidation. N-acetyl cysteine (NAC), an analogue the dietary amino acid cysteine, binds aldehydes thus preventing their damaging effect on physiological proteins. We measured systolic blood pressure (SBP), platelet cytosolic free calcium [Ca2+]i tissue aldehyde conjugates induced hypertensive Wistar-Kyoto (WKY) rats examined NAC diet these parameters. Animals age 7 weeks were divided into three groups 6 each treated follows: WKY-control (chow normal drinking water); WKY-Fructose 4% WKY-Fructose+NAC (1.5% chow water). After 11 weeks, pressure, kidney all significantly higher rats. treatment prevented changes. These results suggest that may be cause hypertension elevated calcium.
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