Synthesis of novel bioactive phthalimido-4-methyl pentanoateorganotin(IV) esters with spectroscopic investigation

作者: Muhammad Ashfaq

DOI: 10.1016/J.JORGANCHEM.2005.12.031

关键词: LigandDibutyltin oxideOrganic chemistryMössbauer spectroscopyMedicinal chemistryFourier transform infrared spectroscopyTriphenyltin chlorideCHN analyzerChemistryDimerMonomer

摘要: Abstract The synthesis of monomer, dimer, tricyclohexyl- and triphenyl-tin(IV) complexes with phthalimido-4-methyl pentanoic acid (PMPA) are described characterized by FT IR, CHN analyzer, 1 H, 13 C 119 Sn NMR 119m Mossbauer spectroscopic techniques. In vitro ED 50 , anti-tumor (phytotoxic), anti-yeast, blood pressure heart rate effect, bactericidal, fungicidal as well analgesic bioassays also be carried out. ligand shows excellent activity while the dimer exhibit strong biocidal behavior besides tri-organotin(IV) complexes.

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