The density of calcified plaques and the volume of calcium predict mortality in hemodialysis patients.

摘要: Abstract Background and aim In the general population lipid-rich plaques are prone to rupture healing of plaque involves calcification. Patients undergoing hemodialysis have a severe derangement mineral metabolism calcification arterial tree may different implications. Methods Between 2004 2005, 125 patients (60 men) underwent computed tomography imaging for quantification coronary artery calcium via Agatston Volume methods. Since score is derived by multiplying density volume calcified lesion, Agatston/Volume ratio (AVR) an indication (i.e. accumulation) within plaque. Results were classified as high AVR (>1) or low (≤1) AVR. Survival analyses tested association between all-cause mortality during median follow-up 5 years. The mean age was 57.2±13.5 years; 75% had >1. rate with >1 significantly higher than in ≤1 (Hazard Ratio(HR): 2.46; 95% Confidence Intervals(CI): 1.16–5.21, p ≤0.018). After adjustment confounders, remained independently associated (HR: 2.24; CI: 1.02–4.88, ≤0.042). There significant interaction on mortality. Conclusions Increased independent predictor patients. These data suggest that increased content arteries dialysis index high-risk rather marker stabilization.