作者: William C. Reeves , Louise A. Brinton , Mariana García , María M. Brenes , Rolando Herrero
DOI: 10.1056/NEJM198906013202201
关键词: Relative risk 、 Medicine 、 Oncology 、 Risk factor 、 Sex organ 、 Viral disease 、 Cervical cancer 、 Cancer 、 Uterine Cervical Diseases 、 Papillomaviridae 、 Gynecology 、 Internal medicine
摘要: To evaluate a possible association between infection with human papillomavirus (HPV) and cervical cancer, we performed multicenter case-control study in Latin America of 759 cases invasive cancer 1467 randomly selected age-matched controls. Demographic, sexual, behavioral, other clinical data were obtained by interview, HPV DNA was assayed cervical-swab specimens use filter situ hybridization. Cervical 16 or 18 both strongly associated cancer. detected 62 percent the but only 32 controls, relative risk increased from 2.1 (95 confidence interval, 1.6 to 2.8) 9.1 (6.1 13.6) hybridization reactions increasing strength. Although number sexual partners, age at first intercourse, live births, Pap-smear history also significant factors, strong associations persisted after adjusted for these variables. These observations are consistent hypothesis that genital may have role pathogenesis Other well-known factors identified study, they did not affect