RETRACTED: Radiation therapy for macular degeneration: Technical considerations and preliminary results

摘要: Purpose: This study was undertaken to assess the toxicity and possible benefits from administration of low-dose external-beam irradiation for Age-Related Macular Degeneration (ARMD). The premise treatment is that radiation induces regression and/or promotes inactivation subretinal neo-vasculature, resulting in reabsorption fluid blood thus reducing risk further leakage or bleeding, as well fibrosis. Clinically, beneficial effect could be translated into stabilization visual acuity prevention progression wet type ARMD with possibility some improvement. Methods Materials: Allegheny University Hospitals, Hahnemann, Department Radiation Oncology, treated 278 patients prospectively beginning January 1995 wet-type macular degeneration. Two hundred forty-nine were a total dose 14.40 Gy eight fractions 1.80 over 10-13 elapsed days, 27 20 at 2 per fraction 12-15 days. first two 10.00 five 2.00 Gy. Patients evaluated 2-3 weeks months. A percentage (36.7%) had previously received laser treatments eye, 21.9% once, 5% twice, 9.7% three more. Subjective data collected on all patients. Results: At after 195 (70%) retained their without change, 68 (24.5%) stated they improved vision, 15 (4.8%) vision continued decrease. 3 months treatment, 183 (65.8%) no change vision. 75 (27%) an improvement (7.2%) decrease acuity. Transient acute reactions occurred 14 treated. Conclusion: Our observations this group support conclusion many will have stable age related