The distribution, determinants, and clinical correlates of vertebral osteophytosis: a population based survey.

摘要: OBJECTIVE: Vertebral osteophytes are a characteristic feature of intervertebral disc degeneration. There are, however, few population data concerning the occurrence and clinico-biological correlates vertebral in both dorsal lumbar spine. Our purpose was to determine frequency distribution anterior thoracic spine, their relationship with various putative risk factors, including physical activity obesity, self-reported back pain. METHODS: Men women aged 50 years over were recruited from primary care based registers 5 UK centers. They invited attend for an interviewer administered lifestyle questionnaire, assessment height weight, lateral spinal radiographs. Lateral radiographs evaluated by single observer presence T4 L5 using semiquantitative score (grade): 0 = none, 1 doubtful, 2 mild, 3 moderate, 4 severe. Based on these summary statistics derived: maximum osteophyte grade at any level (MAX), sum grades individual levels (TOT). RESULTS: In total, 681 women, mean age 63.3 years, 499 men, 63.7 studied; 84% men 74% had least one or higher osteophyte. Both (TOT) proportion subjects MAX > =2 greater than increased age. The pattern involvement similar sexes, occurring most frequently T9-10 L3. Increasing body mass index associated more frequent although stronger Heavy activity, particularly young adult life, osteophytosis men. Self-reported pain, ever past year, linked CONCLUSION: within spine our study heavy points mechanical factors being important pathogenesis osteophytosis. Prospective studies needed explore types that increase susceptibility affecting