Apolipoprotein E Genotype and Outcome in Aneurysmal Subarachnoid Hemorrhage

摘要: BACKGROUND AND PURPOSE: Active management of ruptured intracranial aneurysm in subarachnoid hemorrhage is indicated patients with favorable prognosis. Outcome prediction based on patient characteristics and clinical radiological factors. Current grading scales are imprecise, low interobserver reproducibility. Therefore, outcome remains inconsistent decision making becomes difficult, especially for poor grade. METHODS: The possible relationship between apolipoprotein E genotype the suffering spontaneous was investigated. A prospective study conducted all aneurysmal admitted to our unit during a 2-year period. All were managed according standard protocol, treatments given their grading. Patient characteristics, grade, documented. focus 6-month neurological this group after they discharged. RESULTS: Seventy-two Prince Wales Hospital Shatin, Hong Kong, China, from February 1998 2000. Their ages ranged 24 95 years age, mean (SD) age 58.3 (15.0) years. Apolipoprotein epsilon4 found 15 (21%). At 6 months, Glasgow Scale score < or = 3 29 (40%). Univariate analysis showed that older (odds ratio [OR], 1.03; 95% CI, 1.00 1.07; P=0.07) Fisher's grade (OR, 4.5; 1.3 15.2; P=0.01), World Federation Neurological Surgeons 5.8; 1.9 17.8; P=0.002), 6.0; 1.7 21.3; P=0.006) more likely attain unfavorable at months. additional effect remained significant multiple logistic regression model 11.3; 2.2 57.0; P=0.003); gain predictive performance not (P=0.26). CONCLUSIONS: related hemorrhage.