Modern Carbohydrate Microarray Biochip Technologies
作者： A-Jun WAN , Kun WANG , Hong-Cai ZHANG , Hui-Li LI , De-Nong WANG
DOI: 10.1016/S1872-2040(11)60584-7
关键词: Microarray 、 Nanotechnology 、 Solid surface 、 Biochip 、 Molecular interactions 、 Chemistry 、 Rapid response 、 Drug development
摘要: Abstract Carbohydrate microarray (glycochip) is one of modern biotechnologies for monitoring the molecular interactions between carbohydrate ligands and other biomacromolecules. It characterized by microscale, rapid response, high sensitivity high-throughput. widely applicable in many research development fields, including, but not limited to, biology, medicine, clinical diagnostics, drug development, biomaterial biological reagent industry. This article intends to summarize methods that are currently used construction glycochips. We focus on immobilization either chemically modified or non-modified carbohydrates solid surfaces self-assembly procedures production three-dimensional Current challenges future trends glycochips also discussed.
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